Interview with Mary Margaret Stewart, December 18, 2013

Mary Margaret Stewart was interviewed on December 18, 2013 by Michael Birkner about her early life in California and Nebraska during the Great Depression, undergraduate experience at Monmouth University and graduate experience at Indiana University, and early career in the English department at Gettysburg. Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit -- http://gettysburg.cdmhost.com/cdm/landingpage/collection/p16274coll

Interview with Mary Margaret Stewart, March 13, 2014

Michael Birkner continued his interview with Mary Margaret Stewart on March 13, 2014, covering her decades-long career at Gettysburg College, starting under the administration of Willard Stewart Paul in the 1950s and concluding in the 1990s. Topics covered include her academic activities, relationship with other members of the faculty, and thoughts on the college administration over the years. Collection Note: This oral history was selected from the Oral History Collection maintained by Special Collections & College Archives. Transcripts are available for browsing in the Special Collections Reading Room, 4th floor, Musselman Library. GettDigital contains the complete listing of oral histories done from 1978 to the present. To view this list and to access selected digital versions please visit -- http://gettysburg.cdmhost.com/cdm/landingpage/collection/p16274coll

Silent Spring - the lost call

The "silence" in Rachel Carson's Silent Spring1 alludes to the demise of bird populations through reproductive problems and death resulting from exposure to the pesticides of that time, many of which are endocrine active. Endocrine disrupting chemicals (EDCs) are compounds which may interfere with the endocrine system, producing effects that may disrupt the physiologic function of hormones. Early research on EDC exposure in humans and wildlife has focused mainly on reproductive effects of estrogenic chemicals, however recent studies have revealed that effects of estrogenic as well as non-estrogen active chemicals are often more far reaching than the reproductive system, and even mild exposures experienced early in development may have detrimental effects that are maintained throughout adulthood. Here we show trenbolone acetate, an androgen active environmental contaminant used as a growth promoter for cattle, to cause a literal silence in Japanese quail (Coturnix japonica) chicks following a one time embryonic exposure. Vocalizations were not merely lessened; this is the first study to demonstrate an environmental contaminant to cause a complete abolishment of the ability to vocalize. Since many reasons for vocalization in birds are directly linked to survival of the individual and species, the potential for detrimental population effects is a grave possibility for many avian species that may encounter androgen active chemicals in the environment. Many androgen active EDCs are persistent and ubiquitous in distribution, thereforechances for exposure to these chemicals in birds may be high. We hope that powerful, yet subtle effects like the ones presented here will encourage further research with EDCs to expand beyond the traditional focus of reproductive effects of estrogenic chemicals

The effect of abrupt weaning of suckler calves on the plasma concentrations of cortisol, catecholamines, leukocyte, acute-phase proteins and in vitro interferon-gamma production

End of project reportThe objective of this study was to examine the effect of abrupt weaning (inclusive of social group disruption and maternal separation) on the physiological mediators of stress and measures of immune function. Thirty-eight male and 38 female continental calves were habituated to handling for two weeks prior to bleeding. Calves were blocked on sex, weight and breed of dam and randomly assigned, within block, to either a control (cows remain with calves) or abruptly weaned group (calves removed from cows). Animals were separated into the respective treatment groups at weaning (0 h). Calves were bled at – 168 h, 6 h (males only), 24 h, 48 h and 168 h post weaning. At each sampling time an observer scored the behavioural reaction of calves to sampling. Blood samples were analysed for cortisol, catecholamine concentrations (not sampled at –168 h) and in vitro interferon-gamma production, neutrophil :lymphocyte ratio and acute phase protein concentrations. All continuous data were analysed using a split-plot ANOVA, except that collected at 6 h, which was analysed using a single factor ANOVA model. The effects of weaning, calf sex and time and respective interactions were described. Disruption of the established social groups at 0 h, increased (p<0.001) the plasma cortisol concentration and neutrophil: lymphocyte ratio and reduced the leukocyte concentration (p<0.001) and the in vitro interferon-gamma response to the mitogen concanavalin-A (p<0.001) and keyhole limpet haemocyanin (p<0.001) for weaned and control animals, when compared with –168h. Plasma adrenaline and noradrenaline concentrations were not affected by group disruption. There was no effect of weaning or sex on calf behavioural reaction to handling during blood sampling. Plasma cortisol and adrenaline concentrations were not affected by weaning or sex. Plasma noradrenaline concentration was influenced by weaning x sex (p<0.05) and time x sex (p<0.05). The response increased for male calves with weaning and increased with each sampling time post weaning. For heifers the response was not affected by weaning and plasma concentrations decreased at 168 h post weaning. There was no effect of weaning or sex on leukocyte concentration. The neutrophils : lymphocyte ration increased post weaning (p<0.01) and was affected by sex (p<0.05). Weaning decreased (p<0.05) the in vitro interferon-gamma response to the antigen KLH. There was a time x weaning x sex (p<0.05) interaction for fibrinogen concentration but no effect of treatment on haptoglobin concentration. Abrupt weaning increased plasma cortisol and nor-adrenaline concentrations, which was accompanied by attenuation of in vitro interferon gamma production to novel mitogen and antigen complexes up to 7 days post weaning.European Union Structural Funds (EAGGF

Can’t See the Wood for the Trees: The Returns to Farm Forestry in Ireland

working paperThe period 2007-2009 witnessed considerable variability in the price of outputs such as milk and cereals and this was compounded by a high degree of volatility in the price of inputs such as fertilizer, animal feed and energy. Previously, Irish farms have used the returns to off-farm employment as well as agricultural support payments such as the Single Farm Payment (SFP) and the Rural Environmental Protection Scheme (REPS) to protect their living standards against low and uncertain agricultural market returns. However, the downturn in the Irish economy has led to a reduction in the availability of off-farm employment and also the discontinuation of REPS. This may lead to an increase in afforestation on Irish farms, as forestry offers greater certainty through the provision of an annual premium in addition to the SFP. However, the decision to afforest represents a significant long-term investment decision that should not be entered into without careful economic consideration. The aim of this paper is to use the Discounted Cash Flow (DCF) analysis method to calculate the returns to forestry under alternative opportunity costs associated with conventional agricultural activities being superseded. The returns to forestry are calculated using the Forestry Investment Value Estimator (FIVE). These returns were then incorporated in the DCF model along with the returns to five conventional agricultural enterprises, which would potentially be superseded by forestry. This approach allows for the calculation of the Net Present Value (NPV) of three forestry scenarios

Application of Incident Command Structure to clinical trial management in the academic setting: principles and lessons learned

Background Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the ‘gold standard’ management system developed for managing diverse operations in major incident and public health arenas. It enables effective and flexible management through integration of personnel, procedures, resources, and communications within a common hierarchical organisational structure. Conventional ICS organisation consists of five function modules: Command, Planning, Operations, Logistics, and Finance/Administration. Large clinical trials will require a separate Regulatory Administrative arm, and an Information arm, consisting of dedicated data management and information technology staff. We applied ICS principles to organisation and management of the Prehospital Use of Plasma in Traumatic Haemorrhage (PUPTH) trial. This trial was a multidepartmental, multiagency, randomised clinical trial investigating prehospital administration of thawed plasma on mortality and coagulation response in severely injured trauma patients. We describe the ICS system as it would apply to large clinical trials in general, and the benefits, barriers, and lessons learned in utilising ICS principles to reorganise and coordinate the PUPTH trial. Results Without a formal trial management structure, early stages of the trial were characterised by inertia and organisational confusion. Implementing ICS improved organisation, coordination, and communication between multiple agencies and service groups, and greatly streamlined regulatory compliance administration. However, unfamiliarity of clinicians with ICS culture, conflicting resource allocation priorities, and communication bottlenecks were significant barriers. Conclusions ICS is a flexible and powerful organisational tool for managing large complex clinical trials. However, for successful implementation the cultural, psychological, and social environment of trial participants must be accounted for, and personnel need to be educated in the basics of ICS

Alpha9 nicotinic acetylcholine receptors and the treatment of pain

Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms. Even when these medications are used in combination, substantial amounts of pain often remain. It is therefore highly desirable to develop treatments that work through distinct mechanisms of action. While agonists of nicotinic acetylcholine receptors (nAChRs) have been intensively studied, new data suggest a role for selective antagonists of nAChRs. α-Conotoxins are small peptides used offensively by carnivorous marine snails known as Conus. A subset of these peptides known as α-conotoxins RgIA and Vc1.1 produces both acute and long lasting analgesia. In addition, these peptides appear to accelerate the recovery of function after nerve injury, possibly through immune mediated mechanisms. Pharmacological analysis indicates that RgIA and Vc1.1 are selective antagonists of α9α10 nAChRs. A recent study also reported that these α9α10 antagonists are also potent GABA-B agonists. In the current study, we were unable to detect RgIA or Vc1.1 binding to or action on cloned GABA-B receptors expressed in HEK cells or Xenopus oocytes. We review the background, findings and implications of use of compounds that act on α9* nAChRs.11* indicates the possible presence of additional subunits.Fil: McIntosh, J. Michael. University of Utah; Estados UnidosFil: Absalom, Nathan. The University of Sydney; AustraliaFil: Chebib, Mary. The University of Sydney; AustraliaFil: Elgoyhen, Ana Belen. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Farmacología; ArgentinaFil: Vincler, Michelle. Wake Forest University Health Sciences; Estados Unido

The Market Tort in Private International Law

Perhaps the most troublesome of all choice of law questions arises when a plaintiff asserts a cause of action for injuries arising from a contractual exchange entered in a market situation. This description embraces some of the most important case types in modern litigation: products liability, securities litigation, industrial accidents, medical negligence, and so on. Outside of private international law cases, these have represented the battlefields of recent tort crises and subsequent reforms. We shall refer to these cases as market torts . They represent the principal subject of analysis in this work. The rules that should apply where a choice of law does not exist is a question about the optimal form of default rules. This question can be answered with reference not only to the scholarship of contract default rules, but to the second analogous literature: the economics of adjudication by rules and standards. A choice of law rule is the product of what Cass Sunstein and Edna Ullmann-Margalit describe as a second-order decision. A strategy used in order to avoid the need to confront a decision-making situation is a second-order strategy; the choice of such a strategy is a second-order decision. Thus, choice of law rules avoid the need for a judge to choose a rule on the basis of a direct comparison, according to some cost-benefit calculus and the facts of the particular case. Instead, a choice of law rule provides a means to avoid the need for such comparison, by permitting the matter to be resolved according to the approach embodied in the second-order choice of law rule. Thus, choice of law rules can be differentiated according to whether or not the second-order choice of law rule takes a simple, low-cost formulation, and whether or not that rule permits the eventual first-order adjudication (wherein the law of the cause is selected) to be simple and low-cost. We show how choice of law methods can usefully be described by this taxonomy, and how, with the benefit of the economic literature on rules and standards, we might choose between and give content to these approaches

The Market Tort in Private International Law

Perhaps the most troublesome of all choice of law questions arises when a plaintiff asserts a cause of action for injuries arising from a contractual exchange entered in a market situation. This description embraces some of the most important case types in modern litigation: products liability, securities litigation, industrial accidents, medical negligence, and so on. Outside of private international law cases, these have represented the battlefields of recent tort crises and subsequent reforms. We shall refer to these cases as market torts . They represent the principal subject of analysis in this work. The rules that should apply where a choice of law does not exist is a question about the optimal form of default rules. This question can be answered with reference not only to the scholarship of contract default rules, but to the second analogous literature: the economics of adjudication by rules and standards. A choice of law rule is the product of what Cass Sunstein and Edna Ullmann-Margalit describe as a second-order decision. A strategy used in order to avoid the need to confront a decision-making situation is a second-order strategy; the choice of such a strategy is a second-order decision. Thus, choice of law rules avoid the need for a judge to choose a rule on the basis of a direct comparison, according to some cost-benefit calculus and the facts of the particular case. Instead, a choice of law rule provides a means to avoid the need for such comparison, by permitting the matter to be resolved according to the approach embodied in the second-order choice of law rule. Thus, choice of law rules can be differentiated according to whether or not the second-order choice of law rule takes a simple, low-cost formulation, and whether or not that rule permits the eventual first-order adjudication (wherein the law of the cause is selected) to be simple and low-cost. We show how choice of law methods can usefully be described by this taxonomy, and how, with the benefit of the economic literature on rules and standards, we might choose between and give content to these approaches